The quality of in-hospital care for terminal patients depends on the application of Nursing Care Systematization, the gold standard among interdisciplinary and multidisciplinary teams. In this sense, it is essential that the nursing staff participate in continuous training programs adopting institutional protocols based on the recommendations of the Ministry of Health in order to provide safe and effective care. This study aims to identify the main difficulties encountered by the nursing staff in providing comprehensive in-hospital care to terminally ill patients in the municipality of Paripiranga / BA. The study was approved by the Ethics and Human Research Committee of the UniAges University Center, under opinion No. 087-2016. This is a descriptive cross-sectional field study with a quantitative approach, carried out at Ismael Trindade Municipal Hospital - Paripiranga / BA. All 13 professionals working in the urgency and emergency sector participated in the study, (5; 38.5%) nurses and (8; 61.5%) nursing technicians. It is observed that the majority of the population is composed of women (N = 9; 68.2%), aged between 20 and 30 years (N = 10; 76.9%), with an average of 24.4%. (SD ± 2.9) and married (N = 11; 84.6%). In the 5-year period of work, only (N = 6; 46.1%) received training on in-hospital care for terminally ill patients, which they obtained through their own resources. Most (N = 12; 92.3%) indicated the institutional protocol of in-hospital care as outdated and limiting care. Other difficulties were also mentioned, such as occupational stress and deficiency in psychological security. All participants pointed to the lack of regulation in the care network, the lack of consumable and permanent materials, patient transportation difficulties and reduced staffing.