Traktirov DS, Artemova VS, Nazarov IR, Karpenko MN, Pestereva NS*
Dopamine (DA) and Serotonin (5-HT) are the most significant neurotransmitters in the Central Nervous System (CNS). Separately, the physiological roles of DA and 5-HT have been studied in detail, and progress has been made in understanding their roles in normal and in various pathological conditions (Parkinson's disease, schizophrenia, addiction, depression, etc.) it has been shown that knockout of the gene encoding DAT leads not only to a significant redistribution of dopamine in the striatum, midbrain, prefrontal cortex, and hippocampus, but also to changes in the production of RNA enzymes of monoamine metabolism, as well as to serious changes in the level of serotonin, most clearly manifested in the cerebellum and spinal cord.
Published Date: 2025-01-10; Received Date: 2023-07-08
