Journal of the Pancreas Open Access

  • ISSN: 1590-8577
  • Journal h-index: 84
  • Journal CiteScore: 35.06
  • Journal Impact Factor: 24.75
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days

Abstract

Leptomeningeal Carcinomatosis from Pancreatic Cancer Associated With Germline BRCA Mutations: Case Reports and Review of the Literature

Andrea L Amico, Rimas V Lukas, Hedy L Kindler

Leptomeningeal carcinomatosis from pancreatic cancer is a rare finding thought to occur late in the natural history of the disease. Here we present two cases of leptomeningeal carcinomatosis from BRCA mutation-associated pancreatic cancer including one patient in whom it developed during treatment with a PARP-inhibitor. We review the literature and discuss the possibility that BRCA-associated pancreatic cancer may have a natural history that is distinct from sporadic cases.

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