Journal of the Pancreas Open Access

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Leptomeningeal Carcinomatosis from Pancreatic Cancer Associated With Germline BRCA Mutations: Case Reports and Review of the Literature

Andrea L Amico, Rimas V Lukas, Hedy L Kindler

Leptomeningeal carcinomatosis from pancreatic cancer is a rare finding thought to occur late in the natural history of the disease. Here we present two cases of leptomeningeal carcinomatosis from BRCA mutation-associated pancreatic cancer including one patient in whom it developed during treatment with a PARP-inhibitor. We review the literature and discuss the possibility that BRCA-associated pancreatic cancer may have a natural history that is distinct from sporadic cases.