Hayrapetyan HG, Babayan LA, Gulyan AK, Sarafyan PK, Danoyan HE, Petrosyan ZS, Meliksetyan AE, Harutyunyan TSG, Danoyan EH and Gabrielyan MT
One hundred hypertensive patients and 70 healthy subjects were on unified regimen. Urine was collected with 4-h portions during 3-5 days. Each specimen was analyzed for electrolytes Na, K, P, Cl, Ca, Mg and microelements Fe, Cu, Zn, Cr, Cd, V. Temporal structure parameters have been estimated by nonlinear least squares method for sinusoidal rhythms and dispersion analysis for nonsinusoidal rhythms. Data of weather indices were received from the hydrometeorological service of the RA. In the healthy subjects in 91% cases of rhythmological investigations urinary excretion macro- and microelements statistically significant rhythms were observed. Acrophases of rhythms were mostly individual. In early stage of hypertension, the rhythms of macro- and microelements were statistically nonsignificant in 22% of cases. Among significant rhythms the infradian ones 46% prevailed. In late stage of hypertension, the rhythms of macro- and microelements were statistically nonsignificant in 32% of cases. In hypertensive patients statistically significant correlative connections between rhythms of water-mineral homeostasis and rhythms of weather indices differ in comparison with the results of practically healthy subjects.