Yohannes Belay*, Bamlaku Enawgaw , Feyissa Challa , Meron Sileshi, Amha Gebremedhin and Ketsela Yirdaw
Background Tumor lysis syndrome is one of a catastrophic cŽn�?ŝ�?ŝŽn of mƵů�?ŝ�?ů�? metabolic derangements that occur in bulk and rapidly dividing cancer. It is most commonly associated with hematological malignancies and results in ƐŝŐnŝĨŝc�?n�? mortality and morbidity. The aim of this study was to determine the incidence and factors �?r�?�?ŝc�?ŝnŐ laboratory tumor lysis syndrome in �?�?�?ŝ�?n�?Ɛ with hematological malignancies. Methods A �?rŽƐ�?�?c�?ŝv�? cohort study was conducted on 49 �?�?�?ŝ�?n�?Ɛ diagnosed with hematological malignancies at Tikur Anbessa specialized hospital from September 2017 to April 2018. Data and blood sample were collected �?Ĩ�?�?r Ő�?�?�?ŝnŐ wrŝ�?�?�?n informed consent from the �?�?�?ŝ�?n�?Ɛ�? Laboratory tumor lysis syndrome was assessed based on the Cairo and Bishop �?�?Ĩŝnŝ�?ŝŽn criteria using daily measured laboratory values of uric acid, potassium, phosphate and calcium. A regression analysis was used to assess the Ɛ�?�?�?ŝƐ�?ŝc�?ů �?ƐƐŽcŝ�?�?ŝŽn between incidence and factors �?r�?�?ŝc�?ŝnŐ laboratory tumor lysis syndrome. Results The incidence of laboratory tumor lysis syndrome (LTLS) was 30.6% with 4.1% spontaneous and 26.5% new onset of LTLS. White blood cell count ≥ 25x109/L (AOR: 5.47, 95% CI: 1.11-26.96), lactate dehydrogenase level ≥2 �?ŝm�?Ɛ upper limit normal (AOR: 8.97, 95 % CI: 1.73-46.45)and age ≥ 60 years (AOR: 8.75, 95 % CI: 1.27-60.56) were independent factors �?r�?�?ŝc�?ŝnŐ LTLS. Conclusion More than one-fourth of �?�?�?�?n�?Ɛ with hematological malignancies developed LTLS. Increased baseline white blood cell count, lactate dehydrogenase level and age were the main factors �?r�?�?ŝc�?ŝnŐ LTLS. Keywords: Tumor lysis syndrome; Hematological malignancy; Incidence; White blood cell count.
