British Journal of Research Open Access

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In vitro Comparative Degradation Study of Different Brands of Domperidone Using UV Spectrophotometer

Md. Jakaria, Abul Hasanat and Md Ibrahim Tarek

Objective: The aim of the study was to perform forced degradation studies of the different brands of Domperidone 10 mg.
This drug was subjected to different stress conditions as per International Conference on Harmonization guidelines (ICH). An ultraviolet UV spectroscopic method was developed for analysis of the drug in the presence of the degradation products. Distilled water was used as a solvents. The amount of degraded drugs was calculated by taking the absorbance at 287 nm.
Results: According to the assay limit of USP specified that the content should not be less than 95% and not more than 105% of labelled amount. All brands were degraded by after the heat exposure. On addition of basic pH and acidic pH, all brands were also degraded.
It was concluded that all brands degraded from ranges for all the stresses applied for degradation studies.