Average article processing time (30-45 days)
Less than 5 volumes 30 days
8 - 9 volumes 40 days
10 and more volumes 45 days
Abstract
Hepatic Glucagon Receptor (GCGR) Signaling to Drive Alpha Cell Hyperproliferation and Pancreatic Neuroendocrine Tumor Formation.
Dantas M. Alva
Hypoglycemia causes the pancreatic alpha cells to produce glucagon, which promotes hepatic glucose synthesis. Deregulated glucagon secretion is linked to type 2 diabetes, and elevated glucagon levels contribute to diabetic hyperglycemia. Endocrine cells of the pancreatic islets are known as alpha cells (α-cells). They make up to 20% of human islet cells, which synthesize and secrete the peptide hormone glucagon, which raises blood glucose levels.
Published Date: 2022-03-28; Received Date: 2022-02-21
