Chaudhari Shilpa Pravin, Pacharne Priyanka Sadashiv, Ratnaparkhi Mukesh P
The objective of the research was firstly to investigate the behavior of Surelease (release retardant binder) alone and in combination with other hydrophilic polymers on the release of zidovudine from sustained release matrix tablet. Secondly, to compare between the release pattern of polyethylene oxide and Methocel K100M alone and in combination. A randomized surface methodology (RSM) was applied to study the effect of polymers on drug release. The independent variables of the formulation were: the type of polymers (X1), concentration of polymers (X2) in the tablet and dependent variables are the percentage drug release at 2 hours (Y1) and the percentage drug release at 12 hours (Y2). Release kinetics were analyzed using zero-order, first order, higuchi’s square root and korsmeyer-peppas empirical equations in terms of r2. Results of invitro drug release kinetics study suggests that, all formulations follows zero order kinetics with r2 value in range of 0.99 and fitting the release data to korsmeyers equation release exponent n ranged from 0.83 to 1.22 and followed non-Fickian diffusion mechanism (anomalous transport) and super case II transport for Surelease formulations. Among all the formulations, F14 matrix tablet containing combination of Surelease and polyoxWSR301 shows 102.37% of drug release at the end of 12 hours.
