Biochemistry & Molecular Biology Journal Open Access

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Evaluation of Kidney Injury Molecule-1, Cystatin C, and Serum Electrolytes in Streptozocin Induced Diabetic Rats Treated with Moringa oleifera Leaf Powder

Arvin Nwakuilite, Nwanjo HU, Nwosu DC and Emmanuel Ifeanyi Obeagu*

This work was done to determine the kidney injury markers in streptozocin-induced diabetic rats treated with Moringa oleifera leaf. This was conducted using 5 groups of 10 rats each were used. Group-1 negative control, Group-2 positive control (diabetics), Groups 3 and 4 treated with 150 mg/kg and 300 mg/kg of Moringa oleifera leaf respectively. The parameters analysed includescystatinc C, kidney injury molecule-1 and electrolytes. P-values p<0.05 were considered statistically significant. The study showed that there was no significant difference in the CYS-C levels of all the rats across the group. Also there was a significant decrease in the KIM-1 values of the rats in group 4 (1.72-0.39) when compared with those in group 1, 2 and 3 (2.30 ± 0.38, 2.35 ± 0.30 and 2.76 ± 0.39) respectively, Also, there was no significant difference in the serum electrolyte values of all the rats across the groups, indicting absence of severe kidney injury. From this study, it could be inferred that Moringa oleifera leaf powder used in treatment of streptozocininduced diabetes in rats metabolic acidosis and reduced the toxic damage to the kidney and liver.