Jagdish Badgujar, Dhananjay More and Jyotsna Meshram
Objectives: The objective of this endeavour is to prepare β- cyclodextrin (β-CD) inclusion complex with sulfonamide (SAP) using the co-evaporation technique and screened its effect on in-vitro antimicrobial property against some Gram-positive and Gramnegative bacteria.
Methods: A new sulfonamide SAP (4-amino-N-(1, 5-dimethyl-3- oxo-2-phenyl-2, 3-dihydro-1H-pyrazol-4-yl) benzene sulfonamide) 4 has been synthesized by using Ampyrone with N-Acetylsulfanilyl chloride and characterized by FT-IR, NMR, and LC-MS spectroscopy. The inclusion complex of 4 with β-CD is achieved in the semi aqueous medium by using Sonicator and is characterized with the help of UV–Vis, Fourier Transform Infrared spectrometer, Scanning Electron Microscope, Differential Scanning Calorimetry, Thermo gravimetric Analyzer. Finally, effect of in-vitro antimicrobial activity of the inclusion complex has been studied with the free SAP.
Results: Successful conversion of the new Sulfonamide to its inclusion complex with β-CD has been achieved by co evaporation method. In- vitro antimicrobial studies of both SAP and its inclusion complex with β-CD shows the better enhancement in Inclusion complex across the free Sulfonamide.
Conclusion: The above study shows that inclusion complex of sulfonamide with β-CD offers a simple and attractive solution to improve the bioactivity of pharmaceutical and pharmacokinetic properties of Sulfonamide.
