Journal of Drug Abuse Open Access

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Drug Dependent Stress and Heat Shock Protein Response

Lutfi Tutar, Kubra Acikalin Coskun, Yusuf Tutar

Stress induces radicals and this process triggers several biochemical pathways but most essential problem is the damage caused by the radicals on lipids, proteins, and nucleic acids. To perform biochemical functions, these macromolecules must be working properly. Proteins must be correctly folded so that they can regulate pathways and transmit signals. Under stress, alteration in cellular environment cause proteins to lose their structure. Then, the proteins either lose or alter their function. To scavenge radicals and to chaperone substrate proteins, a set of mechanic proteins are employed.