British Journal of Research Open Access

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Correlation between gestational variables and cardio metabolic risk in adolescence is sex dependent

Mariana Luna

“Metabolic Indicating that programming” intrauterine Growingbody of evidence supports the essential to offspring healthin subsequent life stages. Adverse situations during this periodof life, like maternal overweight or poor maternal diet, can influenceneuroendocrine and energetic balance from the fetusthrough lifelong time1-7. Thus, impacts of maternal nutritionalstatus on cardiovascular risk parameters in adolescent offspringhave been increasingly observed1-3,8,9. However, recent studies,mainly in animals, have been indicating that pregnancy canaffect the developing fetus in different ways, depending on sex,where boys would be more affected than girls 10-16.MethodsThis is a cross-sectional study with 49 adolescents, performedin an Adolescent Health Center in state of Rio de Janeiro, Brazil.Adolescent variables were collected in a scheduled visit, whensociodemographic (sex and age), clinical (diastolic and systolicblood pressure), anthropometric (weight, height, BMI andwaist circumference [WC]), biochemical (glucose, total cholesterol,LDL-c, HDL-c, triglycerides and leptin) and at birth(birth weight and gestational age) variables were evaluated.ConclusionBased on the results from this study, maternal anthropometricvariables were correlated with anthropometric and biochemicalvariables in boys, in a moderate to very-strong way. Hence, forgirls, the only correlations observed were in relation to leptin,and in a weak degree. It suggests that maternal nutritionalstatus may influence adiposity, its Methylation of DNAduring critical periods of development can occur.