Sara Osman*, Yousef M. Al Talhi, Hani Alsawadi, Maha Azzam, Mohammed Humoodi, Abdullah Alzahrani, Amir Shehzad, Mohammed Bakhsh
Objective: To identify the incidence and risk factors for Central Venous Catheter-Related Thrombosis (CVC-RT) among patients admitted to the pediatric intensive unit. Design: Prospective observational study Setting: King Abdulaziz Medical City, a tertiary care center in the western region of Saudi Arabia. Patients: Pediatric patients aged one to 168 months who were admitted to the PICU and required central line insertion (whether inserted centrally or peripherally) more than 48 hours were included. Screening for thrombosis was done within day 4-7 post line insertion and again on day 14. Interventions: None Measurements and main results: A total of 255 patients were enrolled over a period of 17 months. The incidence rate of CVC-RT was 5.4%. The type of CVC was significantly different between the two groups; in the no thrombosis group, 59.2% had central-line while in the CVC-RT groups and 51.9% had PIC line (p=0.027). In a multivariate regression analysis including patients’ clinical profile, high d-dimer as baseline and low platelets were both significant risk factors for CVC-RT (adjusted OR=3.22, CI (1.25-8.28), p=0.015 and adjusted OR=7.38, CI (2.18-25.02), p=0.001), respectively. Conclusions: The current study found out that PIC-line was associated with increased risk of CVC-RT, which is congruent with the literature. As children with CVC can have multiple risk factors to develop CVC-RT, it is important to conduct further large prospective studies to identify such factors and decrease the incidence of CVC-RT.
Published Date: 2025-02-18; Received Date: 2024-02-21
