European Journal of Experimental Biology Open Access

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Antibacterial activity of some coumarine derivatives

Sevdije Govori, Sabrije Spahiu,Arben Haziri and Hamide Ibrahimi

4-(2-(benzyloxy) phenyl amino)-2-oxo-2H-chromene-3-carbaldehyde, (2), 4-(3,5-dichloro pyridin-2-yl amino) -2-oxo -2H-chromene-3-carbaldehyde(3),4-(4-methoxy benzo[d]thiazol-2-yl amino)-2-oxo-2H-chromene-3-carbaldehyde (4), have been isolated in good yields by the action of corresponding aryl and heterorylamines (a-c), on 4-chloro-coumarin-3-carbaldehydes (1) under reflux reaction conditions. Antimicrobial properties of new coumarins (2-4) are investigated and results are submitted for their activities against Staphylococcus aureus, Escherichia coli, Hafnia alvei, Pseudomonas aeruginosa and Enterobacter cloacae. Applying the Agar disc diffusion technique we measured diameters of the inhibition zone around discs which are previously wetted with N, N-DMF solution of compounds, 0.1, 0.3 and 0.5 mg /ml. The inhibition zone depends from concentrations and also from sort of bacteria. The inhibition zone differ from 0 to 39 mm. Two kinds of bacteria, Hafnia alvei and Pseudomonas aeruginosa, are resistant to these new synthesized compounds. From results we may conclude that these derivates showed moderate to high activity against Staphylococcus aureus, Escherichia coli and Enterobacter cloaco. Compounds (2-4) are more active against Staphylococcus aureus, E.coli and Enterobacter cloaco. Compounds (2-4) are not active against Hafnia alvei and Pseudomonas aeruginosa in lower concentration.