European Journal of Experimental Biology Open Access

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Analyzing resistance model of Escherichia coli bacteria detached from urinary tract infection in the presence of antibiotics and magnesium oxide nanoparticles

Morteza Khani, Sara Ostovari, Mohammad Reza Gholami, Mohammad Zolfaghari, Ali Roostaei and Ghasem Rahimi

Urinary tract infection is the most common problem in health sector.The dominant organism involved in this infection is Escherichia coli whose abundance varies in different geographical regions. Keeping in mind the everincreasing consumption and drug resistance against this bacterium, the current study was conducted to analyze resistance model of the respective bacteria in the presence of antibiotics including: ampicillin, ciprofloxacin, cotrimoxazole, cefotaxime, and magnesium oxide nano-particles. In order to separate the respective bacterial species in a sectional experimental test, the completely randomly selected urine samples were tested using standard methods and 214 samples were reported positive in terms of presence of E.coli. Microbial sensitivity analysis was performed in the presence of nano-particles and antibiotics in Mueller-Hinton agar growth medium and the results were analyzed at significance level by means of ANOVA software. In the present research, E.coli bacteria exhibited the highest resistance against ampicillin antibiotic (80%) and the lowest resistance against ciprofloxacin (22%). The maximal and minimal effectiveness of nanoparticles of nanoparticles were respectively achieved at concentrations of 0.3 mg/ml (93%) and 0.08 mg/ml (83%). Results showed that drug resistance is increasing in the respective bacteria and appropriate solutions must be devised for prevention. Taking into account their antibacterial potential, nanoparticles are suitable substitutes for antibiotics.