Maryam Mahdavi Afshar, Mohaddeseh Parsay, Meisam Gholami, Alex Avakian, Farid Salahshour Moghanloo, Mohammad Niatibozchelloei, Seyed Alireza Mousavi, Donya yousefi and Seyed Ali Hosseini Zavareh*
Diabetic foot and diabetic foot ulcer are still a major cause of disability in diabetic patients, and despite many advances in the diagnosis and treatment of diabetes, the problem of diabetic foot has not yet been resolved Researchers have succeeded in treating diabetic foot ulcers with new therapies, including cell therapy. Autologous stem cells derived from peripheral blood mononuclear cells (CD34) are effective in healing diabetic foot ulcers and preventing limb amputation. Several interventional studies have shown that bone marrow aspiration stem cells or peripheral blood mononuclear cells (CD34) can lead to angiogenesis and improve tissue activity in ischemic tissue and help wound healing. Stem cells can also be used which is extracted from adipose tissue, treated diabetic foot ulcers. In this method, induced pluripotent stem cells are used. In another method, a special type of modified blood cells from the umbilical cord called EPC can be used, which Used to speed up the healing and healing of diabetic wounds.