Journal of the Pancreas Open Access

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A First Report of Endoscopic Ultrasound for the Diagnosis of Pancreatic Amyloid Deposition in Immunoglobulin Light Chain (AL) Amyloidosis (Primary Amyloidosis)

Somashekar G Krishna, Manoop S Bhutani, Charles H Mosher, Gregg A Staerkel, Brian R Weston

Context Pancreatic involvement in systemic light chain (AL)-amyloidosis is exceedingly rare. Prior reports of endoscopicultrasound (EUS) for the diagnosis of amyloidosis are also limited. Case report We report the first description of EUS-guided fine needle aspiration (FNA) for the diagnosis of primary AL-amyloidosis involving the pancreas. Conclusion EUS-FNA can be effectively utilized for the characterization and cytologic diagnosis of pancreatic amyloidosis and potentially other accessible extraluminal amyloid deposits.