Journal of Biomarkers in Drug Development Open Access

Introduction

In at least the last 20 years, biomarkers have been more and more incorporated in medicine-based something commonly done and scientific fact-finding experiments in the field of nerve-related medical care. The pace of discovery has been speeding up due to related to computers and science advances with increased high quality and sensitivity of the sensitive measuring and things to be tested, and cross-fertilization from one field of nerve-related medical care to another [1]. The storehouse of biomarkers in nerve-related medical care is likely to keep growing as our ability to measure in a way that's close to the truth or true number multiple related to the body function of living things numbers that change and our knowledge about the how a disease works of the nerve-based sicknesses increase [2].

Biomarkers can be used for more than two, but not a lot of purposes: to guide medicine-based identification of a disease or problem, or its cause, to guess a number disease risk or outlook, to figure out the worth, amount, or quality of disease stage and to watch for changes, unusual things, etc. development or increase over time or things or response to therapy [3]. In scientific factfinding experiments, biomarkers can be used to select a specific disease-identifying subgroup making better, richer, smarter, etc. or separation into clear layers, to secure of appropriate medically helpful target engagement, to identify downstream produces of medically helpful things on the disease process and as a measure of medicine-based effectiveness. The creation of the thermometer was based on the thermoscope of Galileo Galilei. However, Santorio used the artefact to measure the temperature of a human body instead of the external temperature [4]. This way Santorio's device that makes music could be applied to watch for changes, unusual things, etc. a biomarker of infection. Another device created by Santorio is the pulsilogium, aimed at measuring the heart frequency. By measuring related to the body function of living things processes fairly and without emotion, Santorio made key things that are given done to the foundations of biomarkers and high quality medicine. It is reasonable that these things to be tested could be also incorporated in the near future in the identification of a disease or problem, or its cause of synucleinopathies and other sicknesses needed of clearly stated pathophysiological biomarkers.

A major advance in the field of nerve-related medical care has been the development of blood-based biomarkers [5]. Even though there is the existence of initial doubting a lot of things in off to the side markers due to the physical restrictions forced by law by the blood brain something that blocks or stops something, recent related to computers and science advances have made possible to measure analyses in different bio fluids in very low concentrations. The new sensitive measuring devices are mostly based on Simoa or Mass measuring light colours, which provide a best related to careful studying or deep thinking sensitivity.

Conclusion

In years to come, we will see new added exciting biomarkers that will allow detection of nerve-based sicknesses at early disease stages and happening together supervising of multiple related to the body function of living things pathways in response to fancy or smart medically helpful actions that help bad situations. We have to prepare for the very interesting time in history of high quality medicine, a time in history started by Santorio, a time in history the limits of which he could never have imagined.

References

1. Motter R, Vigo-Pelfrey C, Kholodenko D (1995) Reduction of β-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimera's disease. Ann Neurol 38(4):643-648.
2. Blennow K, Hampel H, Weiner M, Zetterberg H (2010) Cerebrospinal fluid and plasma biomarkers in Alzheimerâ??s disease. Nat Rev Neurol 6(3):131-144.
3. Thompson AJ, Banwell BL, Barkhof F (2018) Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 17(2):162-173.
4. Green AJE, Zanusso G (2018) Prion protein amplification techniques. Handb Clin Neurol 153:357-370.
5. Khalil M, Teunissen CE, Otto M (2018) Neurofilaments as Biomarkers in Neurological Disorders. Nat Rev Neurol 14(10):577-589.