European Journal of Experimental Biology Open Access

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Study of analgesic effect of Tragopogon graminifolius hydroethanolic extract in male mice

Zahra Kokabian and Naser Mirazi

Pain is a sensory phenomenon that in many cases it is a sign to identify the disease and mostly has a protective effect. Use of drugs and medicinal plants of the common methods of pain control. Several side effects of chemical drugs such as morphine housing, the more likely people are to use herbal treatment. The aim of this study was to evaluate the analgesic effects of hydroalcoholic extract of Tragopogon graminifolius (HET) in male mice. In this study, 72 male mice were divided in two sections with 6 groups(n=6) including the control group, the morphine groups(1mg/kg), the groups treated with HET at doses of 100, 200 and 400mg/kg, and group treated with naloxone (0.2ml/kg) with dose 200mg/kg of extract were used. For pain assessing in mice the writhing and tail flick tests were used. The data for each test were compared with One-way ANOVA and Tokay post test. Our results indicate that doses of 200 and 400mg/kg HET significantly increased pain threshold compared with the control group in writhing and tail flick tests. Also dose 400mg/kg have been showed mostly analgesic effect in both tests compare with morphine group.In this study, analgesic effect of the HET was observed in the tail flick and writhing tests and this analgesic effect of extract probably related to activation of opioid system.