European Journal of Experimental Biology Open Access

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Protective effect of coadministration of Cassia auriculata and pioglitazone in diabetic rats

Navjot Grover and Pallavi Bafna

The present study was designed to evaluate the effect of coadministration of Cassia auriculata and pioglitazone in alloxan induced diabetic rats. Different groups of diabetic animals were treated with pioglitazone (10 mg/kg, p.o.; 100%), C. auriculata (450 mg/kg, p.o.; 100%); and 50:50 and 25:75 combinations of both pioglitazone and C. auriculata, respectively for a period of 28 days. Biochemical parameters like SGPT, SGOT, alkaline phosphatase, total bilirubin, BUN, serum creatinine and LDH were estimated weekly upto 28 days of treatment. The results proved a prominent positive effect of 25:75 combination of pioglitazone and C. auriculata; suggesting that a reduction of 75% of the conventional dose of pioglitazone, supplemented/ combined with 75% dose of C. auriculata (25% reduction in conventional dose), produced protective effects which were comparable to that of 100% pioglitazone (10 mg/kg) with restoration of levels of renal, cardiac and hepatic parameters. The study concluded that coadministration of pioglitazone and C.auriculata may prove to be more beneficial in diabetes than pioglitazone alone; but the clinical appropriateness of the combination has still to be confirmed