European Journal of Experimental Biology Open Access

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Modulatory role of soya beans supplement on lipid profiles and liver enzymes on alloxan-induced diabetic wistar rats

Sada N. M., Tanko Y. and Mabrouk M. A.

This study evaluates the modulatory role of soya beans supplement on lipid profiles and liver enzymes on alloxaninduced diabetic Wistar rats. Twenty Wistar Rats of both sexes weighed between 120-150 grams were used for the study. Induction of diabetes was done by single intraperitoneal injection of Alloxan monohydrate at a dose of 150mg/kg body weight. The animals were fed with 25% and 50% soya bean as supplements for a period two weeks. Glibenclamide was used as a standard anti-diabetic drug and was given orally. At the end of the two weeks of treatment, the animals were sacrificed and blood serum samples were taken from all the groups for the determinations of lipid profiles and liver enzymes. As regards to the lipid profiles there was a significant decrease (P<0.05) in the serum levels of TG and TC in the soya beans supplemented groups when compared with the control unsupplemented group, while there was a significant increase in the serum level of HDL . In relation to the liver enzymes there was a significant decrease (p<0.05) in serum levels of AST,ALP and ALT in the soya beans fed groups when compared to the control group.