Gramatiuk Svetlana
Stomach cancer is one of the leading places in the structure of the cancer incidence of gastro-intestinal tract. According to numerous publications in recent years throughout recorded steady growth of this disease. The aim of the work was to study the dynamics of exchange of the essential amino acid - L-tryptophan in patients with stomach cancer and the rationale for monitoring criteria significant indicators of early diagnosis of cancer pathology and optimization of pathogenetic therapy. Methods: 130 patients at the age from 35 till 76 years with the established diagnosis of stomach cancer were examined and treated using clinical tools and clinical-morphological methods. Tryptophan metabolites, and its metabolism - serotonin, 5-OIUK determined by C. Atack, T. Magnusson. Melatonin has been studied by ELISA with monoclonal antibodies. Results: Studies of exchange of L-tryptophan in patients with stomach cancer at the earliest stage of tumor found no statistically significant changes in the dynamics of serum ammonia, indicant, L -tryptophan and the enzyme activity TAR P <0.05 was observed while the dynamics of steady increase of L-tryptophan, and TAR. Conclusions: Optimization of the pathogenetic therapy of stomach cancer should include a range of therapeutic interventions aimed at normalization of the neuroendocrine regulation of metabolism of L-tryptophan, detoxification, increased antioxidant protection and inhibition of oxidative stress, improving immunological resistance in combination with surgical and chemotherapeutic effects. Monitor the effectiveness of therapeutic measures can be implemented to change the dynamics of exchange of the amino acid metabolite L-tryptophan, which is of great prognostic significance of the outcome of the disease and recovery.
