Eren Guzeloglu*, Emre Akkelle, Nuran Basoglu, Sila Yilmaz, Aysun Boga and Sirin Guven
Introduction and aim: The COVID-19 pandemic or Coronavirus pandemic is a virus outbreak that emerged on November 17, 2019 in Wuhan, the capital of the Hubei region of China. A new Coronavirus, called SARS-CoV-2, was diagnosed after several patients developed pneumonia that developed without a specific cause and did not respond to treatment and vaccines. It was recognized as a pandemic by the World Health Organization (WHO) on 11/03/2020. In our study, it was aimed to retrospectively evaluate the hematological parameters of the cases that we followed in a tertiary education and research hospital pediatric health and diseases clinic.
Materials and methods: COVID-19 positive cases followed between 11/03/2020-01/06/2020 in the pediatric health and diseases clinic of our hospital were determined retrospectively. Symptoms, physical examination findings and laboratory results of the cases were evaluated. This study was started after the approval of the ethics committee.
Results: 150 cases, 73 males and 77 females, were included in the study. The age of the children varies between 2-216 months, with an average of 112 months. When looking at the laboratory parameters, the lowest, highest and average values are respectively WBC: 2500-21500/mm3 (7223) ANS: 810-10030/mm3 (3658), ALS: 640-13250/mm3 (2723), NLR (Neutrophil Lymphocyte Ratio): 0.08-11.2 (2.05), monocyte: 10-6100/mm3 (596.4), eosinophil: 0-930/mm3 (150.2/mm3), Hb: 9.4-17 g/dL (12.9), Plt: 97000-470000/mm3 (255543) MPV:6.5-13.4 (8.93), MCV: 60.9-94 (81.63) RDW: 11.7-36% (13.59), PDW: 8.7-16.7% (15.76) CRP: 0-5.7 mg/L (0.36), AST: 8-97 U/L (25.6) ALT: 7-90 U/L (18.7) LDH: 143-865 U/L(248.8), urea: 1-865 mg/dL (16.9), creatinine: 0.14-1.4 U/L (0.62), troponin (pg/ml): 0-26.5 (1.8), D-dimer (μg/ml): 0-8.79 (0.5) determined.
Discussion and conclusion: In many studies conducted in our country and around the world, the clinical relationship between hematological parameters and COVID-19 infection has been examined. When studies conducted in the USA and China is examined, it is seen that the most common clinical finding in COVID-19 is lymphopenia. In severe cases of COVID-19, there is usually an increase in the neutrophil count. The ratio of Neutrophils to Lymphocytes (NLR) is an important indicator of inflammation, and its high detection is considered significant in terms of systemic inflammation, but it is also accepted as an indicator of poor prognosis in patients. It is thought that there may be a negative relationship between the number of eosinophils and the clinical presentation of the disease. The incidence of thrombocytopenia increases in severe cases of COVID-19. Hematological parameters have an important place in the diagnosis and follow-up of COVID-19. Clinical presentation of the cases and laboratory findings should be evaluated together.
Published Date: 2023-03-17; Received Date: 2023-01-09
