European Journal of Experimental Biology Open Access

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Effects of erythropoetine and oxymetolone coadministration on serum level of malonyldehaldyde, sorbitol dehydrogenase, gluthathione reductase, serum creatinine and BUN after kidney ischemic reperfusion in dog

Amirhossein Golbaz Farsad,Mehrdad Neshat Gharamaleki* and Ghafour Mousavi

The present study was conducted to evaluate the effects of erythropoetine (Epo) and oxymetolone (Oxy) coadministration on serum level of malonyldehaldyde (MDA) , sorbitol dehydrogenase, gluthathion reductase, serum creatinin and BUN after kidney ischemic reperfusion(I/R) in dog. 24 dogs were randomly divided to 4 groups: 1) Control 2) Oxymetolon (3 mg/kg) 3) Erythropoetine (500 IU/kg) 4) Oxymetolone/erythropoetine (3 mg/kg / 500 IU/kg). Blood samples were taken 5 times: Zero day (Before Ischemia), 45 minutes after Ischemia, 24 hour after repefusion, 7 days after Ischemia, 14 days after Ischemia. Serum samples were sent to Labrotary for malonyldehaldyde (MDA), sorbitol dehydrogenase (SDH), gluthathion reductase (GR), serum creatinin (SCr) and BUN Analysis. Administration of oxymetolone and erythropetene alone and in combination decreased serum MDA level significantly in Epo and Oxy/Epo group (p<0.05). Serum SDH leve deeacreased in all groups compare the zero time. But administration of Epo and Epo/Oxy deacreased serum SDH level significantly between different times (p<0.05) and difference in Oxy and Control group was not significant. Additionaly, serum GR level decreased significantly in Epo, Oxy and Epo/Oxy groups in all times compare the zero time (P<0.05). But decrease in control group compare the zero time was not significant. BUN and SCr level did not differ significantly in all groups compare the zero time.