Neurosciences & Brain Imaging Open Access
-
Journal h-index: 1
- Average acceptance to publication time (5-7 days)
-
Average article processing time (30-45 days)
Less than 5 volumes 30 days
8 - 9 volumes 40 days
10 and more volumes 45 days
Muhammad Ali Rajput
Recently uses of herbal therapies and diet rich in flavonoids and vitamins have increased significantly to treat various forms of depression. Hence present study was designed to conduct antidepressant activity of the ethanol extract of Nelumbo nucifera fruit (NNF) in order to ascertain its therapeutic potential. The antidepressant effect was assessed by forced swimming test (FST) using 35 male albino mice weighing 20�??25 g, equally divided in to 5 groups. In FST highly noteworthy decline in duration of immobility was recorded at doses 100 and 200 mg/kg on 15th day i.e. after administration of 14 doses of NNF as compared to control; whereas same doses demonstrated significant decrease as compared to control in duration of immobility after single dose administration i.e. on 2nd day of experiment. Thus NNF have exhibited strong antidepressant effect and proved to have a great potential for therapeutic applications such as depression and comorbidities associated with depression because of the presence of many significant secondary metabolites in it such as flavonoids and vitamins (immune boosters) and thus encourage more preclinical and clinical trials in this field.
