Esat Nama and Abdullah Yakupoglu
Purpose: Intrahepatic biliary tract epithelial cells. It is unclear what the optimal treatment is for locallyadvanced unrespectable ICCs without distant organ metastasis. In this study, we evaluated the effect of the TARE and systemic chemotherapy sequential treatment on overall survival, progression-free survival, and quality of life in unrespectable ICC cases monitored at our centre. Methods and materials: We retrospectively reviewed the medical records of 14 patients who were monitored at our clinic, were diagnosed with ICC, and underwent a combined treatment of SIRT-Y90 and chemotherapy with glass microspheres as the first line treatment. All patients received cisplatin and gemcitabine as a chemotherapy protocol. Results: One patient developed grade 3 neuropathy due to chemotherapy, one patient developed hepatic encephalopathy. There was no need for postponement of chemotherapy or dose reduction in the remaining 12 patients. There were no treatment-related fatalities. The most common adverse events were fatigue and abdominal pain