Rama Michela Stephanie*, Roukia Djoudi, Razafindramanana Jeenath Francelline, Youssouf Loutfi, Ramanitrahasimbola David and Rajaonarison Jean Francois
Rhopalocarpus similis is a plant endemic to Madagascar, traditionally to treat edema and joint pain. Inflammatory paw edema was caused by injection of carrageenan (2%). Pains manifested by abdominal contortions and licking of the sore paw were induced by injection of acetic acid (1.5%) and formalin (2%), respectively. The plant extract at doses of 150 mg/kg and 300 mg/kg, significantly inhibits (p<0.05) edema at 48.27 ± 8.27% and at 52.74 ± 7.90%), respectively. Indomethacin (10 mg/kg) used as a reference anti-inflammatory drug exerts an inhibition of 53.44 ± 7.10%. Untreated edemas of the paws of control mice were inhibited by 19.53 ± 2.79%. The plant extract also decreases the pain manifested by a significant inhibition (p<0.05) of abdominal contortions to 82.98 ± 1.74% with the two doses versus 81.91 ± 2.30% with the indomethacin. At doses of 200 mg/kg and 400 mg/kg of plant extract, the frequencies of licking of the paw were also inhibited at 63.07 ± 3.32% and at 78.46 ± 2.17% (p<0.05), respectively, versus 83.07 ± 3.32% with paracetamol (300 mg/kg) used as reference analgesic. Furthermore, the plant extract does not cause any lethal toxicity at doses of 1.5 g/kg and 3.0 g/kg.
Published Date: 2023-09-29; Received Date: 2023-07-11
